Colgate Colgate Oral and Dental Health Resource Center

Innovative toothpastes to clean and brighten every type of smile.


A toothbrush for every type of smile, designed with comfort and results in mind.


Colgate kids' products make brushing fun and encourage routine use.

Kids' Products

Oral care products available exclusively through dental professionals.

Products From the Dentist

Professional grade oral care, available without a prescription.

Other Oral Care

Every smile is unique and requires a different type of care. Colgate has a solution for every smile.

Search by Benefit
Font size

Dye test can identify oral abnormalities at risk of turning malignant: study

Canadian researchers have discovered that a dye commonly used to identify oral cancers can also be used to predict if pre-cancerous oral abnormalities are likely to become malignant.

Oral lesions that absorb the dye, known as toluidine blue, were six times more likely to turn malignant and contained molecular alterations that are linked to high risk of oral cancer, even at early stages, the multidisciplinary team from several universities and medical centers in British Columbia reported.

In the United States, more than 30,000 people will be diagnosed with oral cancer this year, according to the American Cancer Society. The five-year survival rate for oral cancer has remained steady at 40 to 50 percent over the past several decades.

Toluidine blue is commonly used in diagnosing oral cancers but the Canadian study is the first to link pre-cancerous lesions - usually identified as white or red patches in the mouth - that absorb the dye with a higher risk for squamous cell carcinomas, the Canadian team said.

"The disease is usually identified fairly late in progression" said senior study author Miriam Rosin, Ph.D., director of the BC Cancer Agency's British Columbia Oral Cancer Prevention Program. "At that stage, it is frequently not amenable to the successful intervention we'd like. The whole deal of changing survival outcome is that you have to get at the disease earlier."

"With enough training of those who are doing the screening, the dye should help the clinicians find those patients with lesions that should really be moved forward for assessment," Dr. Rosin added.

Please contact the ADA if you have questions about this article.

©2010 American Dental Association. All rights reserved. Reproduction or republication is strictly prohibited without the prior written permission from the American Dental Association.

09/06/2005  |  |  Legal/Privacy  | Site Map  |  Contact Us
© Colgate-Palmolive Company. All rights reserved.
You are viewing the United States site.