Non-stop* antibacterial action for a full 12 hours with the Dual-Zinc + Arginine technology of Colgate Total
Dual zinc + Arginine stay active throughout the mouth where biofilm is constantly growing to provide non-stop* action against bacterial plaque
4 A clinical study showed superior bacterial reductions in the whole mouth, 12 hours after brushing§4
Limited control
Limited control of biofilms 12 hours after treatment†‡ with an ordinary fluoride toothpaste
Active control
of biofilms 12 hours after treatment† with Colgate Total®1
Non-stop* superior biofilm control¶ for healthier mouths
Harsh Trivadi, M.S.
Associate Director, Early Research Soft Tissue Sciences
"Our studies revealed
Colgate TotalⓇ shields against
bacterial regrowth 12 hours
after brushing.*1-4"
Dr. Carlo Daep
Global Technology, Colgate-Palmolive
“...which provides dynamic biofilms
control, so you can empower
patients to achieve a healthier
mouth.#5-7"
*with 2x daily brushing and 4 weeks continued use.
† Fluorescent microscopy images of in vitro study. Bacterial biofilms treated for 2-minutes with non-antibacterial fluoride or Dual-Zinc + Arginine toothpaste slurry, followed by a 12-hour regrowth period.
‡ Defined as a non-antibacterial fluoride toothpaste. Some bacteria are mechanically removed while brushing.
§ Statistically significant greater reduction of cultivable bacteria on teeth, tongue, cheeks and gums with Colgate Total® vs non-antibacterial fluoride toothpaste at 4 weeks, 12 hours after brushing.
Always on to help deliver comprehensive benefits for the whole mouth
-
Superior bacterial reductions
Teeth
Tongue
Cheeks
Gums
*with 2x daily brushing and 4 weeks continued use.
†Colgate Total® provides superior in vitro delivery, penetration and retention of Zinc through Arginine technology for biomass reductions vs Zinc control toothpaste
‡ Defined as a non-antibacterial fluoride toothpaste. Some bacteria are mechanically removed while brushing.
References: 1. Daep C, et al. August 2019. Data on file. 2. Manus L, et al. J Clin Dent. 2018;29(Spec lss A)A10-19. 3. Manus L, et al. 2021 IADR/AADR/CADR General Session. 4. Prasad K, et al. J Clin Dent. 2018;29(Spec lss A):A 25-3. -
Protection from biofilm damage
Evidence on how non-stop* antibacterial action protects the mouth from biofilm damage
Teeth
Superior protection against biofilms acids
% reduction in acid production
vs. water control (in vitro)1
Sensodyne and Parodontax are trademarks of GlaxoSmithKline or its subsidiaries; and Zendium is a trademark of Unilever Plc.
Tongue
Reduces malodor biofilms and neutralizes odors
4-week clinical study2
Gums
Superior reductions in bacterial protease activity
% reduction vs. ordinary fluoride toothpaste (in vitro)1
Cheeks
Superior results in bacterial plaque
4-week clinical study3
*with 2x daily brushing and 4 weeks continued use.
References: 1. Makwana E, et al. J Dent Res. 2019;98(Spec lss A):3202. 2. Manus L, et al. 2021 IADR/AADR/CADR General Session. 3. Prasad K, et al. J Clin Dent. 2018;29(Spec lss A):A25-3. -
More superior outcomes
Plaque
Colgate Total helped people achieve superior reductions in plaque vs ordinary non-antibacterial fluoride toothpaste
Gingivitis
Colgate Total helped people achieve superior reductions in bacterial vs ordinary non-antibacterial fluoride toothpaste
Calculus
Colgate Total helped people achieve superior reductions in tartar vs ordinary non-antibacterial fluoride toothpaste
Sensitivity
Colgate Total helped people achieve superior reductions in sensitivity vs ordinary non-antibacterial fluoride toothpaste
Whitening
Colgate Total® is clinically proven to reduce stains and stain intensity‡1
Malodor
Colgate Total® is clinically proven to keep breath fresher over 12 hours§3
*Statistically significant reductions vs non-antibacterial fluoride toothpaste (p<0.001).
† After 8 weeks.
‡ Colgate Total® Pro Gum Health Whitening 1450ppm fluoride toothpaste.
§ Statistically significant reduction vs non-antibacterial ordinary fluoride toothpaste 12 hours overnight with continuous use for 3 weeks.
References: 1. Delgado E, et al. J Clin Dent. 2018;29(Spec lss A)A10-19. 2. Seriwatanachai & Mateo, September 2016, internal report. 3. Hu D, et al. J Clin Dent. 2018;29(Spec lss A)A41 -45.
