Dental agenesis is a term that refers to those born without one or more teeth. According to the Oral Health Group, this is the most common congenital (affects you from birth) condition in humans. Oligodontia is a specific type of agenesis that causes you to be born without six or more teeth (not counting wisdom teeth).

Causes of teeth absent from birth include:

• Genetic syndromes
• Inherited characteristics not related to a genetic syndrome (non-syndromic)
• Viral infection during pregnancy
• Metabolic dysfunction
• Exposure to radiation
• Tumors (benign and cancerous)

Missing teeth not only affect your appearance but can impact your ability to chew and your overall oral health. Related problems to your health typically accompany Oligodontia. These missing teeth can cause the reduced size of your alveolar process, lowered height of your face, and other issues in tooth development.

Your genetics have an incredible breadth of impact on your health and development. If one or both of your parents experience a genetic disorder or mutation, it’s not a guarantee that you will develop the same condition.

Genetic causes are varied, given that oligodontia is caused by both genetic syndromes and inherited family traits. Some conditions and genes that alter other processes in your development can also affect your teeth' development.

In addition to being connected with mutations in individual genes, Oligodontia is associated with other genetic conditions, according to Orphanet.

Associated health conditions may include:

• Hypohidrotic ectodermal dysplasia (HED)
• Odonto-onycho-dermal dysplasia (OODD)
• Schöpf-Schulz-Passarge syndrome (SSPS)

Genes connected with the development of oligodontia include:

• MSX1
• PAX9
• LTBP3
• WNT10A
• EDA
• EDARADD
• IKBKG

There’s no way to know on your own if you’ve inherited mutations in these genes unless you’ve received genetic screening, sequencing, or professional diagnosis. If you’re interested in finding out about your genetics or associated risk factors, schedule an appointment with your dental or medical professional for expert advice.

Because oligodontia has various underlying causes, the presentation may differ between individuals. Some experience few or no symptoms, while others experience difficulty speaking and chewing or changes to their facial appearance.

Some people with oligodontia are more likely to develop cancer, a condition known as oligodontia-cancer predisposition syndrome. This risk is associated with a mutation in the AXIN2 gene. This condition may increase your chance of developing gastrointestinal polyposis, colorectal cancer, and breast cancer, according to Orphanet.

Important note: It’s vital to detect and treat cancer early, but keep in mind that not everyone who experiences oligodontia is at greater risk of cancer. If you believe you have oligodontia, it’s a great idea to schedule an appointment with your dental or medical professional so they can guide your treatment and diagnosis with their expert knowledge.

Replacing your teeth missing from congenital conditions can be challenging, but luckily you have dental professionals at your disposal, including orthodontists, oral surgeons, periodontists, and prosthodontists.

There’s no “one size fits all” solution to oligodontia because your specific case presentation and causes can vary greatly. The alveolar process that connects to the roots of your teeth may be underdeveloped, requiring bone grafting. If your bite is misaligned, you may benefit from an orthodontic solution like braces.

Options for replacing your missing teeth include:

• Dental implants
• Fixed bridges
• Partial dentures

Oligodontia can be difficult to assess and manage on your own. It’s imperative to schedule an appointment with your dental or medical professional for their insight into your unique case because it can be related to other health conditions and risks. You’ve done a great job preparing yourself by reading up on this condition and its causes.

Oral Care Center articles are reviewed by an oral health medical professional. This information is for educational purposes only. This content is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your dentist, physician or other qualified healthcare provider.