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Cold sores (fever blisters): Causes, symptoms & treatment

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Medically Reviewed By Colgate Global Scientific Communications

Ever been surprised by a mysterious, tingling blister on your lips? It's not just dry lips, it's a virus. The blister is a cold sore, troublesome and contagious. Read on to understand more about cold sores, what causes cold sores and fever blisters, symptoms, treatment options, and prevention methods.

What is a Cold Sore (Fever Blister)?

A cold sore, or fever blister, is a small, fluid-filled blister typically appearing around the mouth or lips. The blisters form clusters and are caused by the type-1 herpes simplex virus (HSV-1), also known as oral herpes. The World Health Organisation estimates that about 67% of the global population aged under 50 has this virus.

Most people get infected in early childhood and the likelihood increases with age. While many remain symptom-free, 20% to 40% of those infected experience cold sores. These sores are highly infectious and spread through direct or indirect contact. They usually heal on their but tend to recur once infected.

What Causes Cold Sores?

Cold sores are primarily caused by HSV-1, which spreads from person to person and can re-infect over time. Once infected, the virus remains in the body forever.

  • Herpes Infection: Most people contract HSV-1 in childhood when their immune systems are not fully developed. Symptoms include fever and sores which appear as small blisters on lips. The virus then remains dormant in a cluster of nerve cells in the face called the trigeminal ganglion. 

  • Re-infection: Dormant viruses can reactivate due to factors like cold or fever moving towards the mouth and causing cold sores.

  • Spreading: The herpes virus spreads through direct or indirect contact with the fluid from an  infected person's sores. It can pass through saliva, droplets, or contaminated glasses or utensils. 

Different factors can trigger an outbreak of cold sores:

  • Emotional or mental stress

  • Skin irritation from sun exposure or sunburn

  • Dental treatment

  • Physical strain or trauma

  • Hormonal changes (e.g., pregnancy or menstruation)

  • Illness such as cold, flu, or fever

Cold Sore Symptoms

Cold sores tend to recur, with some people experiencing outbreak once or twice a year, while others may have up to five episodes annually. Subsequent cold sore outbreaks are usually less severe than those in the first. Initial outbreak cold sore symptoms include:

  • Fever

  • Weakness

  • Headache

  • Swollen lymph nodes

  • Vomiting

  • Sore throat

  • Open sores in the mouth

Cold sores progress through stages, mostly appearing on the lips and exterior of the mouth. Rarely, HSV-1 can affect the skin of the fingers, eyes, or genitals, even though the HSV-2 virus is predominantly responsible for genital herpes. The various cold sore stages include:

  • Tingling Sensations: Fever blister on lip causes itching or burning sensation around the lips before the sores develop.

  • Blister formation: Painful fluid-filled lesions break out.

  • Crusting: Blisters merge, rupture and crust over into scabs that gradually fall off as they heal.

Cold sores are often mistaken for canker sores. While cold sores are contagious and appear outside the mouth, canker sores are non-infectious ulcers inside the mouth.

Complications of Cold Sores

Cold sores can be uncomfortable for those who experience them. While they may get better without specific treatment, certain conditions can make a fever blister on lip quite complicated. These conditions include:

  • Bacterial infections resulting in blisters with red borders, pus inside the blisters, and even fever. 

  • Cold sores that spread to the eyes (painful red eye), fingers, or other parts of the body. 

  • Herpes virus causing ulcer on the cornea that can damage vision.

In such cases, immediate medical attention should be sought for early prevention and treatment. 

Cold Sore Treatment

Cold sores heal or clear up naturally, but they can be painful and inconvenient. Here are some common cold sores treatment options:

  • Over-the-counter medications: Antiviral creams, gels, or ointments that can be applied directly at the first sign of the sore.

  • Oral antiviral medications: Prescribed antiviral pills like ibuprofen and acetaminophen can  facilitate  faster healing.

  • Intravenous antiviral medicine: For severe cases, an intravenous antiviral medication may be prescribed.

How Can You Prevent Cold Sores?

Prevention focuses on avoiding the spread of HSV-1 and managing outbreak triggers. Tips include:

  • Avoid physical skin contact or close contact, especially with children and infants, if you are infected.

  • Do not share eating utensils, drinking glasses, and other cutlery.

  • Do not share personal items like razors, toothbrushes, towels, lip balm, or lipstick to avoid cold sore on lip.

  • Maintain good personal hygiene, including washing hands before touching your face.

  • Use sunscreen and lip balm, avoid physical strain, manage stress, and stay healthy.

  • Practice good oral hygiene to prevent potential oral risk factors such as inflammation from bacterial infections. 

When to See a Dental Professional?

 It is ideal to consult a healthcare provider immediately if: 

  • A cold sore that does not heal within two weeks

  • Sores on hands, eyes and genitals

  • Blisters that are numerous, frequent or severely painful

  • A newborn has cold sores 

  • You have underlying health conditions such as eczema or weakened immune system 

  • To get a proper diagnosis and cold sores treatment

Understanding what causes cold sores, their symptoms, and treatment options can help manage outbreaks effectively. Prevention is key to keeping the outbreaks at bay. Additionally, consulting a dental professional is recommended, as they can swab the blister and test the fluid for HSV to get the right diagnosis and treatment.

Frequently Asked Questions

  1. Are cold sores and fever blisters the same?
  2. Yes, cold sores and fever blisters are the same and are often used interchangeably and caused by the herpes simplex virus type 1 (HSV-1). While the term "fever blisters" may indicate their connection to fever, especially a symptom in the first outbreak, cold sores can appear even without one.

  3. How long do cold sores last?
  4. A typical cold sore may last one to two weeks before healing completely. Professional cold sores treatment can speed up the healing process over home remedies.

  5. How to cure cold sores?
  6. There is no cure, but they can be managed through professional treatments involving prescribed oral antivirals or topical medicines that help ease the symptoms and reduce the healing time and discomfort.

  7. Is there a permanent cure for cold sores?
  8. No, the virus remains in the body, but professional cold sores treatment help manage outbreaks, and preventative measures help combat them effectively.