Colgate prescription fluoride toothpastes and mouthwashes are prescribed by your dentist if it’s determined you need to incorporate a high-fluoride oral care product into your routine. This may be due to high cavity risk, crown and bridge work, orthodontic decalcification, or other concerns. What’s the difference between prescription toothpastes and over the counter varieties? As an example, prescription toothpaste like Colgate PreviDent® 5000 Plus contains 1.1% sodium fluoride, delivering four times more fluoride compared to over the counter toothpastes! Follow your dentist's recommendations on how to use a Colgate prescription fluoride toothpaste as you would any other prescription oral care.