How Do You Treat Hypophosphatasia?
Until recently, HPP treatment only included managing and alleviating symptoms caused by the disease. This varied from ventilator support for infants with respiratory insufficiency to low-calcium diets and pain relief techniques. Your physician might also recommend seeking genetic testing and counseling to establish the likelihood of passing the disorder to future generations.
In October 2015, the Food and Drug Administration approved asfotase alfa for use in the United States after clinical trials showed promising results in treating HPP presenting before the age of 18. Asfotase alfa (AA), also known by the brand name Strensiq, is administered through injections. Drug Design, Development and Therapy notes that AA treatment results in improved skeletal mineralization, leading to increased respiratory status and infant survival. It can also alleviate other complications related to bone abnormalities to improve physical function, mobility, and growth.
If you know the HPP gene runs in your family or notice early signs of this disease, seek the advice of a medical professional. Your physician or dental professional can help you determine the best way to alleviate symptoms and take care of your bones and teeth.