The National Institutes of Health defines hypophosphatasia (HPP) as a heritable disorder that weakens bones and teeth at different life stages. It interferes with the metabolism of a substance called alkaline phosphatase, which affects the mineralization process. Mineralization is important for making your teeth and bones rigid and strong.
HPP has degrees of severity typically determined by the timing of the symptoms. Males and females are affected equally, reports the National Organization of Rare Diseases (NORD). The most severe form of HPP may be life-threatening, and the least severe classification may only cause dental abnormalities. Generally, the younger the person is at diagnosis, the more severe and problematic their condition.