New dry mouth treatments investigated

Disabling dry mouth can be an unfortunate side effect of oral cancer treatments, leaving some people unable to ever again produce sufficient saliva due to radiation damage to the salivary gland.

Scientists at the National Institute of Dental and Craniofacial Research hope that they can uncover a way to repair or regenerate salivary glands to solve the problem. Matthew Hoffman, Ph.D., leads the Matrix and Morphogenesis section at NIDCR, and he is the senior investigator on the salivary gland development project. His team is busy identifying cells, signals and other factors that are key in the development of embryonic salivary glands.

Dr. Hoffman's team learned that there is a communication between cells that ultimately leads to a process of innervation—or the development of nerve fibers—in the development of the salivary gland. One type of cell involved has the potential to change into a number of cell types. The scientists theorize that these cells, known as progenitor cells, have potential use in salivary gland regeneration and repair.

"For a cancer survivor who is unable to make much or any saliva, progenitor cells could be isolated from the patient's body and then transplanted inside the diseased gland along with the factors they need to enhance or restore the ability to make saliva," Dr. Hoffman said.

The American Dental Association's consumer information website,, has information on dry mouth—also called xerostomia—its causes, complications and treatment options. For more information this NIDCR salivary gland experiment, visit and search for "Spying on Cellular Cross Talk."

© 2017 American Dental Association. All rights reserved. Reproduction or republication is strictly prohibited without the prior written permission from the American Dental Association.

More Articles You May Like

Dry Mouth


Known by its medical term, xerostomia (zeer-oh-stoh-mee-ah), dry mouth is when you do not have enough saliva to keep your mouth wet and moisturized.


Dry mouth can occur when the glands in the mouth that make saliva are not working properly. Some common causes include:

  • Stress
  • Certain medications
  • Cancer therapy (radiation/chemotherapy)
  • Autoimmune disorders such as Sjogren’s syndrome
  • Smoking

Related Conditions

Dry mouth got you feeling parched?

Dry mouth can leave your mouth feeling dry and irritated. Try one of our toothpastes formulated to help prevent the occurrence of dry mouth symptoms after brushing.